Anti-CD41 (αllb integrin,GPllb)
Antigen CD41 or αIIb subunit is an integrin family protein that is paired with the β3 subunit, which is important for both outside-in and inside-out signalling contributing to cell adhesion. αIIbβ3 integrin (also known as glycoprotein (GP) IIbIIIa) is the most abundant receptor on the platelet surface and is required for platelet aggregation. CD41 is also expressed on hematopoietic stem cells and is important for hematopoietic cell proliferation and development. Our unique anti-CD41 monoclonal antibodies are generated in human αIIb transgenic mice immunized with wild-type mice platelets or in C57 wild-type mice immunized with human αIIb transgenic mice platelets.
Product Table at-a-glance
Characterization of anti-human/murine αIIb monoclonal antibodies
Monoclonal antibodies were generated in C57 wild-type mice (immunized with human αIIb transgenic mice platelets) or human αIIb transgenic mice (immunized with C57 wild-type platelets). Subtype and binding to platelets were analyzed by flow cytometry using washed human/mouse platelets pre-incubated with 5 μg/mL of monoclonal antibodies and then incubation with FITC-conjugated anti-mouse IgM, IgG, IgG1, IgG2a, IgG2b, and IgG3 secondary antibodies. M: Mouse; H: Human