Anti-CD61 (β3, GPIIIa)
Antigen CD61, also known as β3 subunit, is an integrin family protein that pairs with αIIb or αV subunits, which is important for both outside-in and inside-out signalingcontributing to cell adhesion. αIIbβ3 integrin (i.e. glycoprotein (GP) IIbIIIa) is the central receptor of platelet aggregation. αVβ3 integrin plays a critical role in angiogenesis. Our anti-CD61 monoclonal antibodies are generated inhybridoma cells isolated from β3 knockout mice immunized with purified recombinant human β3 integrin.
Product Table at-a-glance
Characterization of anti-β3 integrin monoclonal antibodies
β3-/- mice were immunized with wild-type mouse platelets or purified human β3 integrin. Isotype and binding to platelets were analyzed by a flow cytometric assay by using washed platelets pre-incubated with 5ug/mL of monoclonal antibodies and then incubated with FITC-conjugated anti-mouse -IgG, -IgG1, -IgG2a, -IgG2b and IgG3. M: mouse, H: human, R: rat, P: pig